Efficacy of a novel adaptable and moldable synthetic polymer, in open socket preservation without a membrane: ease of use and volume preservation in alveolar bone regeneration
 
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1
MEDICARE Stomatologia sp. z o.o., Mireckiego 13a/11, 05-300 Mińsk Mazowiecki
 
2
Department of Oral Surgery, Medical University of Warsaw, Oczki 4, 02-007 Warszawa
 
3
Department of Transplantology and Central Tissue Bank, Medical University of Warsaw, Chałubińskiego 5, 02-004 Warszawa
 
 
Submission date: 2026-03-26
 
 
Acceptance date: 2026-04-28
 
 
Publication date: 2026-05-08
 
 
Engineering of Biomaterials 2026;(174):09
 
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ABSTRACT
This study evaluates FlexiOss® Dent, a novel biomaterial combining synthetic hydroxyapatite with curdlan, for its potential in dental applications specifically targeting alveolar bone regeneration post-extraction. Alveolar bone volume loss following tooth extraction significantly compromises dental implant viability and presents challenges in predictable prosthetic reconstruction. Traditional bone grafts, including autografts and allografts, are associated with limitations such as donor site morbidity, resorption, immunologic reactions, and ethical concerns related to animal-derived materials. In this single-patient case study, a 45-year-old patient with persistent mandibular pain underwent extraction of tooth 37, followed by socket preservation using FlexiOss® Dent. The biomaterial was hydrated, sectioned, and layered within the socket to provide structural support, promote angiogenesis, and facilitate osteogenesis. Over a 110-day follow-up period, CBCT imaging and histopathological analysis confirmed effective bone regeneration and integration, with no evidence of vertical or horizontal bone resorption. Favorable soft tissue healing and maintenance of alveolar ridge dimensions were also observed, indicating stable integration of the graft. FlexiOss® Dent’s moldability, porosity, and non-animal-derived composition support its ethical and clinical advantages over conventional graft materials. These findings suggest that FlexiOss® Dent may represent a promising alternative for alveolar ridge preservation and complex dental reconstructions, although larger controlled studies and long-term evaluations are required to validate its broader clinical applicability.
eISSN:3071-7825
ISSN:1429-7248
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