Physical properties of biodegradable polymers exposed to artificial plasma flow
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Faculty of Biomedical Engineering, Silesian University of Technology, Franklina Roosevelta 40, 41-800 Zabrze, Poland
Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej 34, 41-819 Zabrze, Poland
Submission date: 2023-09-01
Acceptance date: 2023-09-27
Publication date: 2023-09-30
Corresponding author
Alicja Zegartowska
Engineering of Biomaterials 2023;(170):9-13
Despite significant advances in diagnosis and treatment, cardiovascular disease remains a major cause of premature death. Approximately 80% of cardiovascular incidents can be prevented by optimizing risk factor control and lifestyle modification, including dietary change. Treatment of cardiovascular disease, like treatment of other diseases, can be divided into conservative and curative. Conservative treatment is based on pharmacotherapy, while surgical treatment is mainly based on the use of PCI (percutaneous coronary intervention) procedures, i.e., increasing blood flow through narrowed arteries. This effect can be achieved with stents. The main limitation of metal stents is their permanent presence within the body, which can lead to complications such as thrombosis. A more advanced solution is the use of polymer or drug-coated stents, both of which are made of biodegradable materials. These stents are designed to release medications to support treatment and maintain their shape within the blood vessel before being naturally absorbed and eliminated by the body. In this study, the surface of stents made of polylactide was modified by applying a layer of PLGA using an ultrasound method. The study was carried out for uncoated and coated stents in both the initial state and after exposure to artificial plasma flow. The scope of the work included microscopic observations, weight measurements of the specimen, and examination of radial forces. The analysis of the results showed no clear effect of exposure on stent weight, but a clear effect of long-term exposure on radial forces was observed.
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